Have you heard of Glutamine?
Glutamine is a non-essential amino acid naturally present in the body, serving as a vital energy source for rapidly regenerating cells. This amino acid has been extensively studied for its beneficial effects on the gastrointestinal (GI) tract, and it is particularly well-known in the field of oncology. Recently, glutamine has garnered interest for its potential benefits in managing GI disorders.
How Glutamine Works
Glutamine supports the body in several ways:
- Promotes New Cell Growth: Encourages the regeneration of healthy cells.
- Decreases Intestinal Permeability: Helps prevent “leaky gut,” a condition where weakened junctions between cells in the GI tract allow harmful substances to enter the bloodstream.
- Suppresses Inflammation: Exhibits antioxidant properties that reduce inflammation.
Glutamine and IBS
For individuals with diarrhoea-predominant Irritable Bowel Syndrome (IBS), decreased levels of glutamine synthetase (an enzyme that breaks down glutamine for cellular use) may contribute to increased intestinal permeability, leading to more frequent diarrhoea. Additionally, glutamine can influence gut microbiota by altering the gut environment, which affects the microbiota’s ability to utilise and digest amino acids.
Research Findings
A recent randomised, double-blind, placebo-controlled study demonstrated that supplementing with 15 grams of glutamine powder daily for six weeks, alongside a low FODMAP diet, significantly reduced IBS symptoms as measured by the IBS-Symptom Severity Score survey. Participants also reported improved quality of life, better stool consistency, and more regular bowel movements.
These results suggest that oral glutamine supplementation can help normalise intestinal permeability, thereby improving GI symptoms in IBS sufferers. This study was the first to explore the combined use of glutamine and a low FODMAP diet for managing IBS, indicating the need for further research to determine the optimal dosage and long-term effects of glutamine supplementation in IBS patients.
Additional Studies
In 2018, the journal Gut published a study focused on post-infectious IBS (PI-IBS). This study found that taking 5 grams of glutamine twice daily over an eight-week period significantly reduced IBS symptom severity compared to a placebo.
Should You Consider Glutamine for IBS?
If you are considering glutamine supplementation to manage IBS symptoms, it is essential to consult with a nutritionist. Individuals with kidney disease, liver disease, or Reye’s syndrome should exercise caution, as glutamine supplements may pose risks for these conditions. You can book a free chat with David Watson, an IBS nutritionist by clicking here.